Prof. Biman Jana

During the Ph.D. studies, I studied the complex dynamics problems associated with liquid crystals, supercooled water and hydration dynamics using computational/theoretical tools. I have handled molecular dynamics software as well as developed code for the analysis of the simulation data. In the last phase of my Ph.D., I have been exposed to the world of biophysics when I was trying to understand the conformational landscape of adenylate kinase. I have used free energy simulation methods to characterize barrier between different conformational states of the enzyme. In my postdoctoral studies, I studied the protein folding problem from the folding funnel and from the principle of minimal frustration point of view. I extended the models to understand complex functional landscape of working molecular motors. I have also built the hybrid models combining physical models of protein with co-evolutionary data to predict the functional landscape of proteins with hidden intermediates and dimeric interfaces. Independently, at IACS, I am working on several biophysical problems using computational and theoretical tools. My group is currently involved in many projects including chemical denaturation of proteins, motor protein dynamics, conformational landscape of protein, studying enzymatic reaction using QM/MM methods, etc.